Molecular Insights into the Enigmatic Metabolic Regulator, SnRK1

S Emanuelle; MS Doblin; DI Stapleton; A Bacic; PR Gooley

Journal article

Molecular Insights into the Enigmatic Metabolic Regulator, SnRK1

S Emanuelle, MS Doblin, DI Stapleton, A Bacic, PR Gooley

Trends in Plant Science | Published : 2016

DOI: 10.1016/j.tplants.2015.11.001

Abstract

Sucrose non-fermenting-1 (SNF1)-related kinase 1 (SnRK1) lies at the heart of metabolic homeostasis in plants and is crucial for normal development and response to stress. Evolutionarily related to SNF1 in yeast and AMP-activated kinase (AMPK) in mammals, SnRK1 acts protectively to maintain homeostasis in the face of fluctuations in energy status. Despite a conserved function, the structure and regulation of the plant kinase differ considerably from its relatively well-understood opisthokont orthologues. In this review, we highlight the known plant-specific modes of regulation involving SnRK1 together with new insights based on a 3D molecular model of the kinase. We also summarise how these ..

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University of Melbourne Researchers

Paul Gooley Author

Related Projects (1)

Explaining the differences in affinity and of carbohydrate binding of the glycogen-sensing enzyme, AMPK

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

This work was supported by Australian Research Council (ARC) Discovery grant DP110103161 (P.R.G. and D.S.) and the ARC Centre of Excellence in Plant Cell Walls (M.S.D., A.B (CE110001007)). S.E was recipient of the Sir John and Lady Higgins Research Scholarship of The University of Melbourne.